EZM2302

EZM2302
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay29954-1 1 mg -

6 - 10 business days*

94.00€
Cay29954-5 5 mg -

6 - 10 business days*

437.00€
Cay29954-10 10 mg -

6 - 10 business days*

823.00€
 
EZM2302 is an inhibitor of protein arginine methyltransferase 4 (PRMT4, IC50 = 6 nM). It... more
Product information "EZM2302"
EZM2302 is an inhibitor of protein arginine methyltransferase 4 (PRMT4, IC50 = 6 nM). It decreases asymmetric methylation of the PRMT4 substrate PABP1 (IC50 = 0.038 µM) and increases levels of demethylated SmB (EC50 = 0.018 µM) in RPMI-8226 multiple myeloma cells. EZM2302 inhibits proliferation in a panel of 36 hematopoietic cancer cell lines, with IC50 values of less than 100 µM for nine of the 15 multiple myeloma cell lines included in the panel. It reduces tumor growth and decreases asymmetric PABP1 methylation in tumor tissue in an RPMI-8226 mouse xenograft model when administered at doses of 75, 150, and 300 mg/kg twice per day. Intrathecal injection of EZM2302 (10 µg) reduces acute mechanical allodynia and thermal hyperalgesia in a mouse model of neuropathic pain induced by chronic constriction injury (CCI).Formal Name: 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylic acid, methyl ester. CAS Number: 1628830-21-6. Synonyms: GSK3359088. Molecular Formula: C29H37ClN6O5. Formula Weight: 585.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=CC=C(OC[C@H](O)CNC)C=C1C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5(CCN(C(OC)=O)CC5)C4)=N2. InChi Code: InChI=1S/C29H37ClN6O5/c1-17-25(24-18(2)34-41-19(24)3)32-26(22-12-21(6-7-23(22)30)40-14-20(37)13-31-4)33-27(17)36-15-29(16-36)8-10-35(11-9-29)28(38)39-5/h6-7,12,20,31,37H,8-11,13-16H2,1-5H3/t20-/m1/s1. InChi Key: OWCOTUVKROVONT-HXUWFJFHSA-N.
Keywords: GSK3359088, 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 29954

Properties

Application: PRMT4 inhibitor
MW: 585.1 D
Formula: C29H37ClN6O5
Purity: >98%
Format: Solid

Database Information

CAS : 1628830-21-6| Matching products
KEGG ID : K05931 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P330, P301+P310, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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