Exatecan (mesylate)

Exatecan is a derivative of camptothecin (Cay-11694) and DNA topoisomerase I inhibitor (IC50 = 0.975 µg/ml). It inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml). Exatecan (3.325-50 mg/kg) reduces tumor growth in an SC-6-JCK gastric adenocarcinoma mouse xenograft model. It reduces tumor weight in HCT116, PC-6, and PC12 mouse xenograft models when administered at a dose of 75 mg/kg. Exatecan has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs). Formulations containing exatecan have been used in the treatment of breast, gastric, and gastroesophageal cancers.Formal Name: (1S,9S)-1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, monomethanesulfonate. CAS Number: 169869-90-3. Synonyms: DX 8951f. Molecular Formula: C24H22FN3O4 . CH3SO3H. Formula Weight: 531.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 224, 261, 337 nm. SMILES: CS(=O)(O)=O.N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62. InChi Code: InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19,1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3,1H3,(H,2,3,4)/t16-,24-,/m0./s1. InChi Key: BICYDYDJHSBMFS-GRGFAMGGSA-N.