EUK 134

Synthetic manganese-porphyrin complexes have been documented to act as scavengers for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro. EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid.Formal Name: chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-kappaN)methylidyne]]bis[6-methoxyphenolato-kappaO]]]-manganese. CAS Number: 81065-76-1. Molecular Formula: C18H18ClMnN2O4. Formula Weight: 416.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): .2 mg/ml. lambdamax: 234, 328 nm. SMILES: [Cl-][Mn+3]12([N]3=CC4=CC=CC(OC)=C4[O-]2)[N](CC3)=CC5=CC=CC(OC)=C5[O-]1. InChi Code: InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22,,/h3-8,11-12,21-22H,9-10H2,1-2H3,1H,/q,,+3/p-3/b19-11+,20-12+,,. InChi Key: YUZJJFWCXJDFOQ-GAMUHHASSA-K.