(+)-Etomoxir (sodium salt)

(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT1), an enzyme that combines fatty acyl-CoAs with carnitine for transport into the mitochondria for beta-oxidation. It inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat hepatocytes, respectively), and it shifts the carbon source for the TCA cycle to glucose. It also inhibits cholesterol synthesis from acetate in hepatocytes upstream of mevalonate. (+)-Etomoxir also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Cay-19284) or UK 5099 (Cay-16980).Formal Name: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid monosodium salt. CAS Number: 828934-41-4. Synonyms: (R)-(+)-Etomoxir. Molecular Formula: C15H18ClO4 . Na. Formula Weight: 320.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml, Water: 10 mg/ml (ultrasonic), Water: 15 mg/ml (ultrasonic at 36°C). lambdamax: 229,282 nm. SMILES: [O-]C([C@]1(CCCCCCOC2=CC=C(Cl)C=C2)OC1)=O.[Na+]. InChi Code: InChI=1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18,/h5-8H,1-4,9-11H2,(H,17,18),/q,+1/p-1/t15-,/m1./s1. InChi Key: RPACBEVZENYWOL-XFULWGLBSA-M.