Etofenamate

Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Cay-21447) that has anti-inflammatory and analgesic activities. It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 µM) and the production of prostaglandin E2 (PGE2, Cay-14010) in stimulated rat peritoneal macrophages. In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively. Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.Formal Name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid, 2-(2-hydroxyethoxy)ethyl ester. CAS Number: 30544-47-9. Molecular Formula: C18H18F3NO4. Formula Weight: 369.3. Purity: >98%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 40 mg/ml, DMSO: 40 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml. lambdamax: 205, 221, 287, 347 nm. SMILES: O=C(OCCOCCO)C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1. InChi Code: InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2. InChi Key: XILVEPYQJIOVNB-UHFFFAOYSA-N.