Ethynyl Estradiol

Ethynyl estradiol is an estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells). It reduces serum cholesterol levels and femur bone mass and increases uterine mass in an ovariectomized (OVX) rat model of postmenopause when administered at a dose of 0.1 mg/kg per day. Ethynyl estradiol also has been found in wastewater effluent, and it prevents secondary sexual development in male fathead minnows (P. promelas) and increases the numbers of intersex fish when used at a concentration of 4 ng/l. Formulations containing ethynyl estradiol have been used as contraceptives.Formal Name: 19-norpregna-1,3,5(10)-trien-20-yne-3,17alpha-diol. CAS Number: 57-63-6. Synonyms: Ethynyl beta-Estradiol, Ethynyl 17beta-Estradiol, Ethynyl 17beta-Oestradiol, Ethynyl E2. Molecular Formula: C20H24O2. Formula Weight: 296.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:7): 0.125 mg/ml. lambdamax: 281 nm. SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O. InChi Code: InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1. InChi Key: BFPYWIDHMRZLRN-SLHNCBLASA-N.