Ethosuximide

Ethosuximide is an anticonvulsant. It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg. Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions. It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ, Cay-18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats. Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days. Formulations containing ethosuximide have been used in the treatment of petit mal seizures.Formal Name: 3-ethyl-3-methyl-2,5-pyrrolidinedione. CAS Number: 77-67-8. Synonyms: CI-366, NSC 64013. Molecular Formula: C7H11NO2. Formula Weight: 141.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1CC(CC)(C)C(N1)=O. InChi Code: InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10). InChi Key: HAPOVYFOVVWLRS-UHFFFAOYSA-N.