ETC-206

ETC-206 is an inhibitor of MAPK-interacting serine/threonine kinase 1 (MKNK1) and MKNK2 (IC50s = 0.064 and 0.086 µM, respectively). It is selective for MKNK1 and MKNK2 over a panel of 104 kinases at 1 µM. ETC-206 inhibits phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) in HeLa cells (IC50 = 0.321 µM). In vivo, ETC-206 enhances tumor growth inhibition induced by dasatinib (Cay-11498) in a K562 mouse xenograft model. It also prevents weight gain in a mouse model of high-fat diet-induced obesity when administered at a dose of 100 mg/kg.Formal Name: 4-[6-[4-(4-morpholinylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]-benzonitrile. CAS Number: 1464151-33-4. Molecular Formula: C25H20N4O2. Formula Weight: 408.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 1 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.2 mg/ml. SMILES: N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=CN32)C=C1. InChi Code: InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2. InChi Key: FWRFPHJSGLYXTD-UHFFFAOYSA-N.