ETC-1002

ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 µM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKbeta1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkbeta1-/- (DKO) mice.Formal Name: 8-hydroxy-2,2,14,14-tetramethyl-pentadecanedioic acid. CAS Number: 738606-46-7. Synonyms: Bempedoic Acid, ESP-55016. Molecular Formula: C19H36O5. Formula Weight: 344.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 20 mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL, Ethanol: 2 mg/mL. SMILES: OC(C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O)=O. InChi Code: InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24). InChi Key: HYHMLYSLQUKXKP-UHFFFAOYSA-N.