Erlotinib (hydrochloride)

Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model. Formulations containing erlotinib have been used in the treatment of various cancers.Formal Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, monohydrochloride. CAS Number: 183319-69-9. Synonyms: CP 358,774, NSC 718781, OSI-774. Molecular Formula: C22H23N3O4 . HCl. Formula Weight: 429.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 222, 246, 345 nm. SMILES: COCCOC(C=C1C(NC2=CC=CC(C#C)=C2)=NC=NC1=C3)=C3OCCOC.Cl. InChi Code: InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22,/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25),1H. InChi Key: GTTBEUCJPZQMDZ-UHFFFAOYSA-N.