ERK Inhibitor

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 µM), A549 lung carcinoma cells (IC50 = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.Formal Name: 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride. CAS Number: 1049738-54-6. Synonyms: Extracellular Regulated Kinase Inhibitor. Molecular Formula: C14H16N2O3S . HCl. Formula Weight: 328.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 2 mg/ml. lambdamax: 238, 354 nm. SMILES: CCOC1=CC=C(/C=C2SC(N(CCN)C\2=O)=O)C=C1.Cl. InChi Code: InChI=1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12,/h3-6,9H,2,7-8,15H2,1H3,1H/b12-9-,. InChi Key: PQVLWVGMXJPJLG-MWMYENNMSA-N.