(-)-Epinephrine

(-)-Epinephrine is an endogenous adrenergic receptor agonist that is released from the adrenal medulla. It binds to alpha1-adrenergic receptors (Ki = 6 µg/L), as well as beta1-, beta2-, and beta3-adrenergic receptors (Kis = 4, 7, and 126 µM, respectively) in radioligand binding assays. (-)-Epinephrine inhibits forskolin-induced adenylyl cyclase activity in CHO cells expressing alpha2-adrenergic receptors (EC50 = 240 nM) and induces cAMP production in primary human tracheal epithelial cells, which endogenously express beta2-adrenergic receptors (EC50 = 640 nM). (-)-Epinephrine (100 µg/kg) reduces ear hyperperfusion and decreases in body temperature and increases survival in a mouse model of anaphylaxis induced by platelet-activating factor (PAF). Formulations containing (-)-epinephrine have been used in the treatment of anaphylaxis.Formal Name: 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol. CAS Number: 51-43-4. Synonyms: Adrenaline, NSC 62786. Molecular Formula: C9H13NO3. Formula Weight: 183.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 281 nm. SMILES: OC1=C(O)C=CC([C@@H](O)CNC)=C1. InChi Code: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1. InChi Key: UCTWMZQNUQWSLP-VIFPVBQESA-N.