Ensartinib

Ensartinib is a potent and selective inhibitor of anaplastic lymphoma kinase (ALK, IC50 50 = 15 nM) but has no effect on cell growth driven by other mutant kinases or that of non-cancerous HepG2 cells. Ensartinib, at a dose of 25 mg/kg, reduces H3122 xenograft growth with no effect on body weight in nude mice. It is also brain-permeable to a concentration of 65 nM.Formal Name: 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide. CAS Number: 1365267-27-1. Molecular Formula: C25H25Cl2FN6O3. Formula Weight: 547.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMF:PBS(pH 7.2)(1:6): 0.14, DMSO: 14 mg/mL, Ethanol: 5 mg/mL. lambdamax: 244, 296 nm. SMILES: ClC1=C([C@H](OC2=C(N)N=NC(C(NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3)=O)=C2)C)C(Cl)=CC=C1F. InChi Code: InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1. InChi Key: ONPGOSVDVDPBCY-CQSZACIVSA-N.