EM12-SO2F

EM12-SO2F is a covalent inhibitor of cereblon (CRBN, IC50 = 0.88 nM). It inhibits the degradation of Ikaros family zinc finger protein 1 (IKZF1) induced by the thalidomide derivative lenalidomide (Cay-14643) in MOLT-4 lymphoblasts when used at a concentration of 1 µM.Formal Name: 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride. CAS Number: 2803819-61-4. Molecular Formula: C13H11FN2O5S. Formula Weight: 326.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C1NC(C(CC1)N2C(C3=CC(S(=O)(F)=O)=CC=C3C2)=O)=O. InChi Code: InChI=1S/C13H11FN2O5S/c14-22(20,21)8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18). InChi Key: IAJNULNMWPZFDR-UHFFFAOYSA-N.