Elvitegravir

Elvitegravir is a quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM). It has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in peripheral blood mononuclear cells (PBMCs, EC50s = 0.3-0.9). Formulations containing elvitegravir have been used in the treatment of HIV infections.Formal Name: 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-3-quinolinecarboxylic acid. CAS Number: 697761-98-1. Synonyms: GS-9137, JTK-303. Molecular Formula: C23H23ClFNO5. Formula Weight: 447.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml. lambdamax: 258, 312 nm. SMILES: ClC1=CC=CC(CC2=CC(C(C(C(O)=O)=CN3[C@@H](C(C)C)CO)=O)=C3C=C2OC)=C1F. InChi Code: InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1. InChi Key: JUZYLCPPVHEVSV-LJQANCHMSA-N.