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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay26114-500 | 500 µg | - |
6 - 10 business days* |
310.00€
|
|||
Cay26114-1 | 1 mg | - |
6 - 10 business days* |
584.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Eltrombopag-13C4 is intended for use as an internal standard for the quantification of... more
Product information "Eltrombopag-13C4"
Eltrombopag-13C4 is intended for use as an internal standard for the quantification of eltrombopag (Cay-13247) by GC- or LC-MS. Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in N2C-Tpo cells when used at a concentration of 30 µM and p42/44 MAPK phosphorylation when used at 10 µM. Eltrombopag binds to the transmembrane domain of the thrombopoietin receptor and stimulates megakaryocytopoiesis in human primary bone marrow cells. It increases platelet production in chimpanzees when administered at a dose of 10 mg/kg per day for five days. Eltrombopag also binds to iron (III) and mobilizes cellular iron and ferritin in H9C2, Huh7, and RINm5F cells in a concentration-dependent manner. It enhances cellular iron mobilization when used in combination with the iron chelators deferasirox (Cay-16753) and CP40.Formal Name: (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-(methyl-13C)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene-3,4,5-13C3)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. Molecular Formula: C21[13C]4H22N4O4. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 0.5 mg/ml, Ethanol: 0.11 mg/ml, PBS (pH 7.2): Slightly Soluble. SMILES: OC1=C(N/N=[13C]2[13C](N(C3=CC(C)=C(C)C=C3)N=[13C]\2[13CH3])=O)C=CC=C1C4=CC(C(O)=O)=CC=C4. InChi Code: InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-/i3+1,16+1,22+1,24+1. InChi Key: XDXWLKQMMKQXPV-PHYJMDTMSA-N.
Keywords: | (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-(methyl-13C)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene-3,4,5-13C3)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 26114 |
Properties
Application: | GC-MS, LC-MS, internal standard, TpoR agonist |
MW: | 446.4 D |
Formula: | C21[13C]4H22N4O4 |
Purity: | >98% |
Format: | Solid |
Database Information
KEGG ID : | K05082 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H312, H315, H319, H332 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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