eFT508

eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = 50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.Formal Name: 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione. CAS Number: 1849590-01-7. Molecular Formula: C17H20N6O2. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 237, 357 nm. SMILES: NC1=NC=NC(NC2=CC(C)=C(C(NC34CCCCC4)=O)N3C2=O)=C1. InChi Code: InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21). InChi Key: HKTBYUWLRDZAJK-UHFFFAOYSA-N.