E6446 (hydrochloride)

E6446 is an antagonist of toll-like receptor 7 (TLR7) and TLR9 (IC50s = 1.78 and 0.01 µM, respectively). It is selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM). E6446 inhibits IL-6 production induced by the TLR9 agonist CpG ODN2216 or TLR7 agonist RNA40 in isolated mouse bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner. It prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of heart failure induced by transverse aortic constriction when administered at a dose of 1.5 mg/animal. E6446 (10 mg/kg) increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of pulmonary hypertension induced by the alkaloid monocrotaline (Cay-16666). It has also been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro.Formal Name: 6-[3-(1-pyrrolidinyl)propoxy]-2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-benzoxazole, dihydrochloride. CAS Number: 1345675-25-3. Molecular Formula: C27H35N3O3 . 2HCl. Formula Weight: 522.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): Slightly soluble. lambdamax: 258, 276, 317 nm. SMILES: C1(C2=CC=C(C=C2)OCCCN3CCCC3)=NC4=C(C=C(C=C4)OCCCN5CCCC5)O1.Cl.Cl. InChi Code: InChI=1S/C27H35N3O3.2ClH/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30,,/h7-12,21H,1-6,13-20H2,2*1H. InChi Key: DQOUZINBHKWGGM-UHFFFAOYSA-N.