E6446 dihydrochloride
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs,... more
Product information "E6446 dihydrochloride"
Description: E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs, potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. Target: TLR. Smiles: Cl.Cl.C(COc1ccc(cc1)-c1nc2ccc(OCCCN3CCCC3)cc2o1)CN1CCCC1. References: Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar,85(3):429-40.
| Supplier: | TargetMol |
| Supplier-Nr: | T4068 |
Properties
| Application: | TLR7 / TLR9 antagonist |
| MW: | 522.51 D |
| Formula: | C27H37Cl2N3O3 |
Database Information
| CAS : | 1345675-25-3| Matching products |
| KEGG ID : | K10161 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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