(E)-SIS3
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: (E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-beta1-dependent... more
Product information "(E)-SIS3"
Description: (E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-beta1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-beta1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-beta2-induced endothelial cell differentiation in iPSCs. Target: TGF-beta/Smad. Smiles: Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12. References: Jinnin M, et al. Mol Pharmacol. 2006, 69(2):597-607.
| Keywords: | SIS3, SIS3 HCl |
| Supplier: | TargetMol |
| Supplier-Nr: | T3636 |
Properties
| Application: | Selective Smad3 inhibitor |
| MW: | 489.99 D |
| Formula: | C28H27N3O3·HCl |
Database Information
| CAS : | 521984-48-5| Matching products |
| KEGG ID : | K04500 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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