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![DYRK1A/B Inhibitor AnnH75](https://www.biomol.com/media/image/21/f8/e5/AG-CR1-3651-C500_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-CR1-3651-C500 | 500 µg | - |
3 - 9 business days* |
154.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Pale yellow solid. Soluble in DMSO. Potent selective membrane-permeable DYRK1A (IC50=181nM) and... more
Product information "DYRK1A/B Inhibitor AnnH75"
Pale yellow solid. Soluble in DMSO. Potent selective membrane-permeable DYRK1A (IC50=181nM) and DYRK1B inhibitor. Off-target inhibition of CLK1, CLK4 and Haspin/GSG2, Shows no inhibitory effects on monoamine oxidase A (MAO A), Inhibited the cotranslational tyrosine autophosphorylation of DYRK1A and threonine phosphorylation of an exogenous substrate protein with similar potency, Dose-dependently reduced the phosphorylation of three known DYRK1A substrates (SF3B1, SEPT4 and tau) without negative effects on cell viability in celular assays, Moderate inhibitor of CDK8, CLK2, GRK4, MEK2, PIM1, PIM3 and PKCepsilon, Shows minimal cytotoxic effects in HeLa and PC12 cells up to 10µM, The pleiotropic protein kinase DYRK1A has diverse functions in cell cycle control, neuronal differentiation and synaptic transmission and has attracted increasing interest as a potential drug target, due to its role in the pathology of Down syndrome, neurodegenerative diseases such as Alzheimer's disease and cancer. The closely related kinase DYRK1B has been associated with cancer cell survival by arresting cells in a quiescent state to allow cellular repair and mutations in DYRK1B might be causative in metabolic syndrome.
Keywords: | 2-(1-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-9-yl)acetonitrile, AnnH75 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-CR1-3651 |
Properties
Application: | Potent selective membrane-permeable DYRK1A / DYRK1B inhibitor |
MW: | 271,7 D |
Formula: | C14H10ClN2O |
Purity: | >98% |
Format: | Solid |
Database Information
KEGG ID : | K08825 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H319 |
P Phrases: | P264, P280, P305+P351+P338, P337+P313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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