Dyclonine (hydrochloride)

Dyclonine is a topical anesthetic that also has antimicrobial, anticancer, and neuroprotective properties. It is active against S. aureus, B. subtilis, E. coli, P. vulgaris, P. aeruginosa, C. albicans, M. lanosum, and T. mentagrophytes with minimum microbicidal concentrations (MMCs) ranging from 0.006 to 0.8% v/v. Dyclonine (25-100 µM) reduces aldehyde dehydrogenase (ALDH) activity in and viability of HSC-4 oral squamous cell carcinoma cells and enhances HSC-4 and OSC19 cell death induced by sulfasalazine (Cay-15025). In vivo, dyclonine (5 mg/kg per day) reduces tumor volume in an HSC-2 mouse xenograft model when administered alone or in combination with sulfasalazine. Dyclonine also induces cerebral frataxin (FXN) production and decreases time to cross and the number of foot slips in a level beam test in a mouse model of Friedreich's ataxia.Formal Name: 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride. CAS Number: 536-43-6. Synonyms: Dyclone, Dyclothane, Tanaclone. Molecular Formula: C18H27NO2 . HCl. Formula Weight: 325.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 221, 279 nm. SMILES: O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl. InChi Code: InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19,/h7-10H,2-6,11-15H2,1H3,1H. InChi Key: KNZADIMHVBBPOA-UHFFFAOYSA-N.