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Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 µg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa (Cay-23783), indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.Formal Name: (betaR),3-dihydroxy-L-tyrosine. CAS Number: 23651-95-8. Synonyms: L-threo-3,4-Dihydroxyphenylserine, L-Dihydroxyphenylserine, L-DOPS, SM 5688. Molecular Formula: C9H11NO5. Formula Weight: 213.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Slightly Soluble. SMILES: OC1=C(O)C=CC([C@@H](O)[C@H](N)C(O)=O)=C1. InChi Code: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1. InChi Key: QXWYKJLNLSIPIN-JGVFFNPUSA-N.
Keywords:
L-threo-3,4-Dihydroxyphenylserine, L-Dihydroxyphenylserine, L-DOPS, SM 5688, (betaR),3-dihydroxy-L-tyrosine
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