Doxazosin (mesylate)

Doxazosin is a non-selective antagonist of alpha1-adrenergic receptors (alpha1-ARs, Kis = 3.16, 1, and 3.98 nM for alpha1A­-, alpha1B-, and alpha1D-ARs, respectively). It inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.Formal Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monomethanesulfonate. CAS Number: 77883-43-3. Synonyms: UK 33274-27. Molecular Formula: C23H25N5O5 . CH3SO3H. Formula Weight: 547.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/mL, DMSO: 2 mg/mL, DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL. lambdamax: 247, 330 nm. SMILES: COC1=C(OC)C=C(C(N)=NC(N2CCN(C(C3COC(C=CC=C4)=C4O3)=O)CC2)=N5)C5=C1.OS(C)(=O)=O. InChi Code: InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20,1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26),1H3,(H,2,3,4). InChi Key: VJECBOKJABCYMF-UHFFFAOYSA-N.