Doxazosin-d8 (hydrochloride)

Doxazosin-d8 is intended for use as an internal standard for the quantification of doxazosin (Cay-18633) by GC- or LC-MS. Doxazosin is a non-selective antagonist of alpha1-adrenergic receptors (alpha1-ARs, Kis = 3.16, 1, and 3.98 nM for alpha1A-, alpha1B-, and alpha1D-ARs, respectively). It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.Formal Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monohydrochloride. CAS Number: 1219803-95-8. Molecular Formula: C23H17D8N5O5 . HCl. Formula Weight: 496.0. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile:Methanol (1:1): soluble, DMSO: soluble. SMILES: COC1=C(OC)C=C(C(N)=NC(N2C([2H])([2H])C([2H])([2H])N(C(C3COC(C=CC=C4)=C4O3)=O)C([2H])([2H])C2([2H])[2H])=N5)C5=C1.Cl. InChi Code: InChI=1S/C23H25N5O5.ClH/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20,/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26),1H/i7D2,8D2,9D2,10D2,. InChi Key: AQAZIYFEPYHLHC-SJEKSWIZSA-N.