Dorsomorphin (hydrochloride)

Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK, Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 µM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.Formal Name: 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine, dihydrochloride. CAS Number: 1219168-18-9. Synonyms: BML-275, Compound C, CpdC. Molecular Formula: C24H25N5O . 2HCl. Formula Weight: 472.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 238, 271, 334, 366 nm. SMILES: N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC=C5)C=N4)C=C2)CCCCC1.Cl.Cl. InChi Code: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20,,/h4-11,16-18H,1-3,12-15H2,2*1H. InChi Key: RJDVIJJQKMGPMV-UHFFFAOYSA-N.