Dopamine D3 Receptor Agonist 13a

Dopamine D3 receptor agonist 13a is a dopamine D3 receptor agonist. It selectively binds to dopamine D3 over dopamine D1, D2, and D4 receptors (Kis = 0.14, 4,600, 2.85, and 756 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 6, 54, 1.47, and 252 nM, respectively), however, it is a partial agonist of dopamine D2 receptors (EC50 = 2.26 nM in a G protein recruitment assay) and acts as an antagonist at dopamine D3 receptors (IC50 = 4.62 nM). Dopamine D3 receptor agonist 13a (3 mg/kg) reduces cocaine self-administration in rats.Formal Name: N-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-3-methoxy-propanamide. CAS Number: 2899250-94-1. Molecular Formula: C22H33Cl2N3O2. Formula Weight: 442.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, Ethanol: 3 mg/ml. lambdamax: 220 nm. SMILES: ClC1=CC=CC(N2CCN(CC[C@H]3CC[C@H](NC(CCOC)=O)CC3)CC2)=C1Cl. InChi Code: InChI=1S/C22H33Cl2N3O2/c1-29-16-10-21(28)25-18-7-5-17(6-8-18)9-11-26-12-14-27(15-13-26)20-4-2-3-19(23)22(20)24/h2-4,17-18H,5-16H2,1H3,(H,25,28)/t17-,18-. InChi Key: NOSXOCMQQISHPL-IYARVYRRSA-N.