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Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor). It is selective for Piezo1 activated by yoda1 (Cay-21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4 (TRPC4) at 10 µM. Dooku1 (10 µM) reduces the percentage of cells with yoda1-induced extracellular phosphatidylserine exposure in red blood cells (RBCs) isolated from patients with sickle cell anemia. Preincubation with dooku1 (10 µM) inhibits yoda1-induced relaxation of isolated mouse aortic rings.Formal Name: 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole. CAS Number: 2253744-54-4. Molecular Formula: C13H9Cl2N3OS. Formula Weight: 326.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 296 nm. SMILES: ClC1=CC=CC(Cl)=C1CSC2=NN=C(C3=CC=CN3)O2. InChi Code: InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2. InChi Key: MNPOBXLPCWFONX-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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