Domperidone

Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor). It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM). Domperidone (0.5-5 µg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors. Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Cay-28546) in dogs. It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.). Domperidone also increases serum levels of prolactin in male rats.Formal Name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one. CAS Number: 57808-66-9. Synonyms: KW 5338, NSC 299589. Molecular Formula: C22H24ClN5O2. Formula Weight: 425.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 209, 287 nm. SMILES: O=C(NC1=C2C=CC=C1)N2CCCN3CCC(N4C(C=CC(Cl)=C5)=C5NC4=O)CC3. InChi Code: InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30). InChi Key: FGXWKSZFVQUSTL-UHFFFAOYSA-N.