Dofetilide
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium... more
Product information "Dofetilide"
Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. Target: Potassium Channel. Smiles: N(S(C)(=O)=O)C1=CC=C(CCN(CCOC2=CC=C(NS(C)(=O)=O)C=C2)C)C=C1. References: Kiehn J, et al. Circulation, 1996, 94(10), 2572-2579.
| Keywords: | UK 68789, UK-68798, Tikosyn |
| Supplier: | TargetMol |
| Supplier-Nr: | T6476 |
Properties
| Application: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| MW: | 441.56 D |
| Formula: | C19H27N3O5S2 |
Database Information
| CAS : | 115256-11-6| Matching products |
| KEGG ID : | K04905 | Matching products |
| Protein Atlas Nr. : | Neuropharmacologics/Ion Channel Modulators |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H360 |
| P Phrases: | P201, P202, P264, P270, P280, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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