Docosanol

Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication). It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells. It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Cay-14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane. Formulations containing docosanol have been used in the topical treatment of HSV-1.Formal Name: 1-docosanol. CAS Number: 661-19-8. Synonyms: Behenyl Alcohol, n-Docosanol, Docosyl Alcohol, NSC 8407. Molecular Formula: C22H46O. Formula Weight: 326.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 1.7 mg/ml. SMILES: CCCCCCCCCCCCCCCCCCCCCCO. InChi Code: InChI=1S/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2,1H3. InChi Key: NOPFSRXAKWQILS-UHFFFAOYSA-N.