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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Cay-11216) as a... more
Product information "DMABA-d6 NHS ester"
DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Cay-11216) as a derivatizing reagent for Phosphatidylethanolamine (PE) lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d6 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids. Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured. PE lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.Formal Name: 4-[di(methyl-d3)amino]-benzoic acid, 2,5-dioxo-1-pyrrolidinyl ester. CAS Number: 1175002-04-6. Synonyms: 4-(dimethylamino) Benzoic Acid-d6, DMABA N-hydroxysuccinimide ester-d6, N-Succinimidyl 4-(dimethylamino)benzoate-d6. Molecular Formula: C13H8D6N2O4. Formula Weight: 268.3. Purity: >99% deuterated form (d1-d6). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml. lambdamax: 233, 323 nm. SMILES: O=C(CC1)N(OC(C2=CC=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C2)=O)C1=O. InChi Code: InChI=1S/C13H14N2O4/c1-14(2)10-5-3-9(4-6-10)13(18)19-15-11(16)7-8-12(15)17/h3-6H,7-8H2,1-2H3/i1D3,2D3. InChi Key: FNGFZOAQGYOQTG-WFGJKAKNSA-N.
Keywords: | 4-(dimethylamino) Benzoic Acid-d6, DMABA N-hydroxysuccinimide ester-d6, N-Succinimidyl 4-(dimethylamino)benzoate-d6, 4-[di(methyl-d3)amino]-benzoic acid, 2,5-dioxo-1-pyrrolidinyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11218 |
Properties
Application: | Derivatizing reagent |
MW: | 268.3 D |
Formula: | C13H8D6N2O4 |
Purity: | >99% deuterated form (d1-d6) |
Format: | Crystalline Solid |
Database Information
CAS : | 1175002-04-6| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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