DM1-SMCC

N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine, Cay-22483) and the crosslinker SMCC. ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells. DM1-SMCC conjugated to an anti-CD70 antibody has been used to study the transport of the ADC catabolites into the cell cytoplasm of 786-0 renal cell carcinoma cells.Formal Name: N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine. CAS Number: 1228105-51-8. Synonyms: SMCC-DM1. Molecular Formula: C51H66ClN5O16S. Formula Weight: 1072.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 12 mg/ml. SMILES: C/C(C1)=C\C=C\[C@](OC)([H])[C@](C[C@@](O2)([H])[C@@H](C)[C@H]3[C@](O3)(C)[C@](OC([C@H](C)N(C)C(CCSC4C(N(CC5CCC(C(ON6C(CCC6=O)=O)=O)CC5)C(C4)=O)=O)=O)=O)([H])CC(N(C)C7=CC1=CC(OC)=C7Cl)=O)(O)NC2=O. InChi Code: InChI=1S/C51H66ClN5O16S/c1-27-10-9-11-37(69-8)51(67)25-35(70-49(66)53-51)28(2)45-50(4,72-45)38(24-42(61)55(6)33-21-31(20-27)22-34(68-7)44(33)52)71-47(64)29(3)54(5)39(58)18-19-74-36-23-43(62)56(46(36)63)26-30-12-14-32(15-13-30)48(65)73-57-40(59)16-17-41(57)60/h9-11,21-22,28-30,32,35-38,45,67H,12-20,23-26H2,1-8H3,(H,53,66)/b11-9+,27-10+/t28-,29+,30?,32?,35+,36?,37-,38+,45+,50+,51+/m1/s1. InChi Key: IADUWZMNTKHTIN-MLSWMBHTSA-N.