DL-threo-PPMP (hydrochloride)

DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM). It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons. [Matreya, LLC. Catalog No. 1720]Formal Name: rel-N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride. CAS Number: 139974-41-7. Synonyms: DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol. Molecular Formula: C29H50N2O3 . HCl. Formula Weight: 511.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C(CCCCCCCCCCCCCCC)N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C29H50N2O3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26,/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32),1H/t27-,29-,/m1./s1. InChi Key: ORVAUBQYJOFWFY-ZHESDOBJSA-N.