Diprovocim-1

Diprovocim-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
TGM-T37722-1mg 1 mg

7 - 10 business days*

181.00€
TGM-T37722-5mg 5 mg

7 - 10 business days*

453.00€
TGM-T37722-10mg 10 mg

7 - 10 business days*

792.00€
 
Description: Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces... more
Product information "Diprovocim-1"
Description: Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces TNF-alpha release in THP-1 cells (EC50= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2-/-, mice sensitized to ovalbumin.2It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model. Target: Others. Smiles: O=C(N[C@H]1C[C@@H]1c1ccccc1)[C@@H]1CN(C[C@H]1C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)c1ccc(cc1)C(=O)N1C[C@H]([C@@H](C1)C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)N[C@H]1C[C@@H]1c1ccccc1. References: Morin, M.D., Wang, Y., Jones, B.T., et al.Diprovocims: A new and exceptionally potent class of toll-like receptor agonistsJ. Am. Chem. Soc.140(43)14440-14454(2018)
Supplier: TargetMol
Supplier-Nr: T37722

Properties

Application: TLR1/TLR2 agonist
MW: 909.1 D
Formula: C56H56N6O6

Database Information

CAS : 2170867-89-5| Matching products
KEGG ID : K10159 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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