Diosmetin-d3

Diosmetin-d3 is intended for use as an internal standard for the quantification of diosmetin (Cay-18649) by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively). Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH (Cay-82235) in a concentration-dependent manner. It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day. Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.Formal Name: 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-d3-phenyl)-4H-1-benzopyran-4-one. CAS Number: 1189728-54-8. Synonyms: Diosmetol-d3, Luteolin 4'-methyl ester-d3. Molecular Formula: C16H9D3O6. Formula Weight: 303.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C1C=C(C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C31. InChi Code: InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3/i1D3. InChi Key: MBNGWHIJMBWFHU-FIBGUPNXSA-N. Origin: Synthetic.