Diosmetin

Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively). Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH (Cay-82235) in a concentration-dependent manner. It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day. Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.Formal Name: 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-34-3. Synonyms: Diosmetol, Luteolin 4'-methyl ester. Molecular Formula: C16H12O6. Formula Weight: 300.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 252, 268, 343 nm. SMILES: OC1=CC(O)=C(C(C=C(C2=CC=C(OC)C(O)=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3. InChi Key: MBNGWHIJMBWFHU-UHFFFAOYSA-N.