Dioscin

Dioscin is a natural steroid saponin that was first isolated from plants used in herbal remedies. Early studies indicated that it inhibits proliferation and induces apoptosis in cancer cells. Dioscin has antioxidant activity that can alter cell signaling in cancer cells. It also induces autophagy prior to apoptosis in human lung cancer cell lines.Formal Name: (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside. CAS Number: 19057-60-4. Synonyms: Collettiside III. Molecular Formula: C45H72O16. Formula Weight: 869.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 10 mg/ml. lambdamax: 202 nm. SMILES: C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O[C@]7([H])O[C@H](CO)[C@@H](O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@H](O)[C@H]7O[C@@]9([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O9)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C. InChi Code: InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1. InChi Key: VNONINPVFQTJOC-ZGXDEBHDSA-N. Origin: Plant/Trigonella foenum.