Dinotefuran

Dinotefuran is a neonicotinoid insecticide. It is an agonist of nicotinic acetylcholine receptors (nAChRs), inducing inward currents in isolated American cockroach (P. americana) neurons with an EC50 value of 7.6 µM. Dinotefuran, alone or in combination with the metabolic inhibitors piperonyl butoxide (PB, Cay-25820) or propargyl propyl benzenephosphonate (NIA), induces mortality in adult P. americana. It is lethal to insecticide-sensitive or -resistant strains of A. gambiae, C. quinquefasciatus, and A. aegypti in larval (LC50s = 0.14-0.44 mg/L) and adult (LD50s = 0.18-31.16 ng/mg) bioassays. Dinotefuran has been found in a variety of commercial foodstuffs, including rice, cucumber, milk, egg, and pork samples, as well as in water samples from freshwater streams. Formulations containing dinotefuran have been used in the agricultural and veterinary control of insect infestations.Formal Name: N''-methyl-N-nitro-N'-[(tetrahydro-3-furanyl)methyl]-guanidine. CAS Number: 165252-70-0. Synonyms: 1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine, MTI-446, Nidinotefuran. Molecular Formula: C7H14N4O3. Formula Weight: 202.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 270 nm. SMILES: CN/C(N[N+]([O-])=O)=N\CC1CCOC1. InChi Code: InChI=1S/C7H14N4O3/c1-8-7(10-11(12)13)9-4-6-2-3-14-5-6/h6H,2-5H2,1H3,(H2,8,9,10). InChi Key: YKBZOVFACRVRJN-UHFFFAOYSA-N.