Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![Dimethylamino Parthenolide](https://www.biomol.com/media/image/60/99/a5/Cay20436-10_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay20436-10 | 10 mg | - |
6 - 10 business days* |
175.00€
|
|||
Cay20436-25 | 25 mg | - |
6 - 10 business days* |
366.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-kappaB and a derivative of parthenolide... more
Product information "Dimethylamino Parthenolide"
Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-kappaB and a derivative of parthenolide (Cay-70080). It inhibits the binding of the p65 subunit of NF-kappaB to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine (Cay-20261), NADPH oxidase inhibitor apocynin (Cay-11976), or RIP1 kinase inhibitor necrostatin-1 (Cay-11658). DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.Formal Name: (1aR,4E,7aS,8R,10aS,10bR)-8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one. CAS Number: 791595-09-0. Synonyms: DMAPT, LC-1. Molecular Formula: C17H27NO3. Formula Weight: 293.4. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Miscible, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: Miscible, Ethanol: 30 mg/ml. SMILES: O=C([C@H]1CN(C)C)O[C@@]2([H])[C@@]1([H])CC/C(C)=C\CC[C@]3(C)[C@@H]2O3. InChi Code: InChI=1S/C17H27NO3/c1-11-6-5-9-17(2)15(21-17)14-12(8-7-11)13(10-18(3)4)16(19)20-14/h6,12-15H,5,7-10H2,1-4H3/b11-6-/t12-,13-,14-,15+,17+/m0/s1. InChi Key: UJNSFDHVIBGEJZ-WCOQXKCFSA-N.
Keywords: | DMAPT, (4E,8S)-8-[(dimethylamino)methyl]-2,3,6,7,7aS,8,10aS,10bR-octahydro-1aR,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 20436 |
Properties
Application: | Apoptosis inducer |
MW: | 293.4 D |
Formula: | C17H27NO3 |
Purity: | >99% |
Format: | Crystalline Solid |
Database Information
CAS : | 791595-09-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed