Dimethyl DL-Glutamate (hydrochloride)

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide (Cay-15009) and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in beta-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.Formal Name: 1,5-dimethyl ester glutamic acid, monohydrochloride. CAS Number: 13515-99-6. Synonyms: Glutamic Acid dimethyl ester, Dimethyl 2-aminopentanedioate. Molecular Formula: C7H13NO4 . HCl. Formula Weight: 211.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: COC(C(N)CCC(OC)=O)=O.Cl. InChi Code: InChI=1S/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2,/h5H,3-4,8H2,1-2H3,1H. InChi Key: MFUPLHQOVIUESQ-UHFFFAOYSA-N.