Dimethyl 2-ketoglutarate

Dimethyl 2-ketoglutarate is an esterified form of the citric acid cycle intermediate alpha-ketoglutarate. It increases intracellular levels of alpha-ketoglutarate and decreases intracellular ATP levels in U2OS human osteosarcoma cells cultured in complete- or nutrient-free media when used at a concentration of 5 mM. Dimethyl 2-ketoglutarate inhibits autophagy and decreases in intracellular levels of acetyl-CoA in serum- and nutrient-deprived cells. It decreases cardiomyocyte hypertrophy in a mouse model of cardiac pressure overload induced by thoracic aortic constriction when administered at a dose of 300 mg/kg. Dimethyl 2-ketoglutarate reduces serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and hepatic fibrosis in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4).Formal Name: 2-oxo-pentanedioic acid, 1,5-dimethyl ester. CAS Number: 13192-04-6. Synonyms: 2-KG dimethyl ester, Dimethyl alpha-ketoglutarate, Dimethyl 2-oxoglutarate. Molecular Formula: C7H10O5. Formula Weight: 174.2. Purity: >90%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: COC(CCC(C(OC)=O)=O)=O. InChi Code: InChI=1S/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3. InChi Key: TXIXSLPEABAEHP-UHFFFAOYSA-N.