Dimethindene (maleate)

Dimethindene is a histamine H1 receptor antagonist (Ki = 1.5 nM). It is selective for histamine H1 receptors over M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively). In vivo, dimethindene (0.1 mg/kg), alone or in combination with the osmotic agent icodextrin, decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgery-induced abdominal trauma in rabbits. Formulations containing dimethindene have been used in the treatment of dermatosis, pruritis, and nasal allergies.Formal Name: N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine, 2Z-butenedioate. CAS Number: 3614-69-5. Synonyms: Dimetindene, NSC 107677, SU 6518. Molecular Formula: C20H24N2 . C4H4O4. Formula Weight: 408.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml, Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: O=C(O)/C=C\C(O)=O.CC(C1=CC=CC=N1)C2=C(CCN(C)C)CC3=CC=CC=C23. InChi Code: InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20,5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: SWECWXGUJQLXJF-BTJKTKAUSA-N.