Dilazep (hydrochloride)

Dilazep is an inhibitor of equilibrative nucleoside transporter 1 (ENT1, IC50 = 17.5 nM). It is selective for ENT1 over ENT2 (IC50 = 8,800 nM). Dilazep (0.03 and 0.3 µM) increases adenosine-induced relaxation of, and decreases calcium-induced contractions in isolated guinea pig taenia caeci strips when used at concentrations of 1, 5, and 10 µM. Dilazep (0.2 mg/kg, i.v.) reduces heart rate and systolic, mean, and diastolic aortic pressure and increases left ventricular blood flow in anesthetized dogs. It reduces aortic platelet adhesion and aggregation in a rabbit model of aortic injury-induced thrombosis when administered intravenously at a dose of 0.1 mg/kg.Formal Name: 3,4,5-trimethoxy-benzoic acid, 1,1'-[(tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di-3,1-propanediyl] ester. CAS Number: 20153-98-4. Molecular Formula: C31H44N2O10 . 2HCl. Formula Weight: 677.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Water: Soluble. SMILES: COC1=C(OC)C(OC)=CC(C(OCCCN2CCCN(CCCOC(C3=CC(OC)=C(OC)C(OC)=C3)=O)CC2)=O)=C1.Cl.Cl. InChi Code: InChI=1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4,,/h18-21H,7-17H2,1-6H3,2*1H. InChi Key: VILIWRRWAWKXRW-UHFFFAOYSA-N.