Dihydrocoumarin

Dihydrocoumarin is a coumarin that has been found in M. officinalis and has enzyme inhibitory activity. It inhibits the activities of sirtuin 1 (SIRT1) and SIRT2 (IC50s = 208 and 295 µM, respectively, for the human enzymes). Unlike coumarin, dietary administration of dihydrocoumarin (0.76%) does not induce hepatocyte vacuolation, bile duct hyperplasia, or cholangiofibrosis. Formulations containing dihydrocoumarin have been used as flavoring agents.Formal Name: 3,4-dihydro-2H-1-benzopyran-2-one. CAS Number: 119-84-6. Synonyms: DHC. Molecular Formula: C9H8O2. Formula Weight: 148.2. Purity: >98%. Formulation: (Request formulation change), A liquid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: O=C1OC2=C(CC1)C=CC=C2. InChi Code: InChI=1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2. InChi Key: VMUXSMXIQBNMGZ-UHFFFAOYSA-N. Origin: Synthetic.