Digoxigenin Monodigitoxoside

Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin (Cay-22266). It has a binding affinity of 0.829 and an inhibitory potency of 1.07 relative to [3H]ouabain in a competitive binding assay using purified lamb Na+/K+-ATPase and for its ATPase activity, respectively. Digoxigenin monodigitoxoside is selective for the alpha3beta1 isoform over alpha1beta1 and alpha2beta1 (Kds = 31.8, 65, and 35 nM, respectively). Digoxigenin monodigitoxoside produces a more potent inotropic response in perfused guinea pig hearts than digoxin with 60 and 46% increases in inotropy, respectively.Formal Name: (3beta,5beta,12beta)-3-[(2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. CAS Number: 5352-63-6. Molecular Formula: C29H44O8. Formula Weight: 520.7. Purity: >97%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slighly soluble, Methanol: slighly soluble. SMILES: C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])C[C@@H](O)[C@@]4(C)[C@]3(O)CC[C@@H]4C(CO5)=CC5=O)([H])C[C@@H](O[C@]6([H])O[C@H](C)[C@@H](O)[C@@H](O)C6)CC1. InChi Code: InChI=1S/C29H44O8/c1-15-26(33)22(30)13-25(36-15)37-18-6-8-27(2)17(11-18)4-5-20-21(27)12-23(31)28(3)19(7-9-29(20,28)34)16-10-24(32)35-14-16/h10,15,17-23,25-26,30-31,33-34H,4-9,11-14H2,1-3H3/t15-,17-,18+,19-,20-,21+,22+,23-,25+,26-,27+,28+,29+/m1/s1. InChi Key: JFSXBMIFXZFKHD-ZDDLGXCGSA-N.