Digitoxigenin

Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D. purpurea. It elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase via binding at the digitalis receptor site with nanomolar potency. Digitoxigenin is highly cytotoxic, inhibiting Na+/K+ ATPase-dependent protein synthesis, and has been examined for use as an antitumor compound.Formal Name: (3beta,5beta)-3,14-dihydroxy-card-20(22)-enolide. CAS Number: 143-62-4. Synonyms: Cerberigenin, (+)-Digitoxigenin, Echujetin, Evonogenin, NSC 407806, Thevetigenin, Delta20:22-3,14,21-Trihydroxynorcholenic acid lactone. Molecular Formula: C23H34O4. Formula Weight: 374.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. SMILES: O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O)CC[C@@H]4C(CO5)=CC5=O)([H])C1. InChi Code: InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,19-,21+,22-,23+/m1/s1. InChi Key: XZTUSOXSLKTKJQ-CESUGQOBSA-N.