Diflunisal

Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively). Peak plasma levels are achieved within two hours, with little metabolism before excretion in the urine. The terminal plasma half-life is approximately eight hours.Formal Name: 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. CAS Number: 22494-42-4. Synonyms: 5-(2,4-Difluorophenyl)salicylic Acid, MK-647. Molecular Formula: C13H8F2O3. Formula Weight: 250.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 228, 253 nm. SMILES: FC1=CC(F)=C(C2=CC=C(O)C(C(O)=O)=C2)C=C1. InChi Code: InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18). InChi Key: HUPFGZXOMWLGNK-UHFFFAOYSA-N.