Dienestrol

Dienestrol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay38954-100 100 mg -

6 - 10 business days*

93.00€
Cay38954-250 250 mg -

6 - 10 business days*

220.00€
 
Dienestrol is a synthetic non-steroidal estrogen receptor (ER) agonist and an active metabolite... more
Product information "Dienestrol"
Dienestrol is a synthetic non-steroidal estrogen receptor (ER) agonist and an active metabolite of diethylstilbestrol (Cay-10006876). Dienestrol binds to ERalpha and ERbeta (Kis = 0.05 and 0.03 nM, respectively) and activates ERalpha in a reporter assay (EC50 = 3.23 nM). It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 µM, respectively, in cell-free assays. Oral administration of dienestrol (1.5-6.25 µg/kg) to pregnant rats during gestation and lactation decreases sperm motility and viability and induces prostatitis in mature male offspring. It induces abortions when administered to pregnant rats at 50 and 75 µg/kg. Formulations containing dienestrol have been used in the treatment of atrophic vaginitis and vulvar atrophy.Formal Name: 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-phenol. CAS Number: 84-17-3. Synonyms: Dienoestrol, NSC 59809. Molecular Formula: C18H18O2. Formula Weight: 266.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: OC1=CC=C(C(C(C2=CC=C(C=C2)O)=CC)=CC)C=C1. InChi Code: InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3. InChi Key: NFDFQCUYFHCNBW-UHFFFAOYSA-N.
Keywords: Dienoestrol, NSC 59809, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-phenol
Supplier: Cayman Chemical
Supplier-Nr: 38954

Properties

Application: Diethylstilbestrol active metabolite, synthetic non-steroidal estrogen receptor agonist
MW: 266.3 D
Formula: C18H18O2
Purity: >95%
Format: Solid

Database Information

CAS : 84-17-3| Matching products
KEGG ID : K08551 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H350, H361
P Phrases: P201, P202, P280, P308+313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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