Dicyclomine (hydrochloride)

Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol, Cay-14486) in guinea pig cortex (Ki = 12 nM, pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively. Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.Formal Name: [1,1'-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride. CAS Number: 67-92-5. Synonyms: Dicycloverine. Molecular Formula: C19H35NO2 . HCl. Formula Weight: 346.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 50 mg/ml. SMILES: CCN(CC)CCOC(C1(C2CCCCC2)CCCCC1)=O.Cl. InChi Code: InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17,/h17H,3-16H2,1-2H3,1H. InChi Key: GUBNMFJOJGDCEL-UHFFFAOYSA-N.